Research Articles
GMWI 2.0: Decoding the Gut Microbiome Wellness Index for Predictive Health Analytics and Precision Therapeutics
This article provides a comprehensive technical overview of the Gut Microbiome Wellness Index (GMWI) 2.0 as a predictive biomarker for human health status.
Greengenes vs SILVA vs RDP: A 2024 Guide for Researchers Choosing a 16S rRNA Database
This comprehensive guide provides biomedical and drug development researchers with a critical comparison of the three dominant 16S rRNA gene databases: Greengenes, SILVA, and RDP.
De Novo Phylogenetic Tree Construction with the Greengenes Database: A Step-by-Step Guide for Researchers
This article provides a comprehensive guide to de novo phylogenetic tree construction using the Greengenes database, tailored for researchers, scientists, and drug development professionals.
Inferring Microbial Dynamics: A Practical Guide to Granger Causality for Time Series Microbiome Networks
This article provides a comprehensive framework for applying Granger causality to infer directed interaction networks from longitudinal microbiome data.
Unveiling the Microbiome Network: A Comprehensive Guide to Gaussian Graphical Models for Microbial Interaction Analysis
This article provides a detailed guide to Gaussian Graphical Models (GGMs) for inferring microbial interaction networks from high-throughput sequencing data.
Zero-Inflated Generalized Poisson Factor Analysis with GLMs: A Powerful Tool for Modern Drug Discovery and Biomarker Research
This article provides a comprehensive guide to GLM-based Zero-Inflated Generalized Poisson Factor Analysis (ZIGPFA), a sophisticated statistical framework designed for high-dimensional count data with excess zeros, prevalent in modern biomedical...
Longitudinal Microbiome Analysis with GEE-CLR-CTF: A Comprehensive Guide for Biomedical Researchers
This article provides a comprehensive guide to the GEE-CLR-CTF model, a sophisticated statistical framework for analyzing longitudinal microbiome data.
Beyond the Zeros: Advanced Filtering Strategies for Zero-Inflated Microbiome (OTU) Data Analysis
This article provides a comprehensive guide for researchers and bioinformaticians tackling the pervasive challenge of zero-inflation in Operational Taxonomic Unit (OTU) tables.
Faith's Phylogenetic Diversity (PD) Explained: Definition, Calculation, and Applications in Biomedical Research
This article provides a comprehensive guide to Faith's Phylogenetic Diversity (PD), a cornerstone metric in biodiversity science with growing importance for drug discovery and microbiome research.
FTA Cards for Fecal Sample Storage: A Complete Guide to Room Temperature Biobanking for Researchers
This comprehensive guide explores the application of Flinders Technology Associates (FTA) cards for the stabilization and room-temperature storage of fecal samples.